Structure of frequency-interacting RNA helicase from Neurospora crassa reveals high flexibility in a domain critical for circadian rhythm and RNA surveillance.

The FRH (frequency-interacting RNA helicase) protein is the Neurospora crassa homolog of yeast Mtr4, an essential RNA helicase that plays a central role in RNA metabolism as an activator of the nuclear RNA exosome.FRH is also a required component of the circadian clock, mediating protein interactions that result in the rhythmic repression of gene e

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Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder

Ashley Brenton,1 Steven Richeimer,2,3 Maneesh Sharma,4 Chee Lee,1 Svetlana Kantorovich,1 John Blanchard,1 Brian Meshkin1 1Proove Biosciences, Irvine, CA, 2Keck school of Medicine, University of Southern California, Los Angeles, CA, 3Departments of Anesthesiology and Psychiatry, University of Southern California, Los Angeles, CA, 4Interventional Pai

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Engineering Design, Kinematic and Dynamic Analysis of High Lugs Rigid Driving Wheel, a Traction Device for Conventional Agricultural Wheeled Tractors

Traction failure on loose terrain is common in conventional agricultural wheeled tractors due to poor Lunch Bags traction ability and lower power transfer efficiency of drive wheels, which leads to excessive energy consumption and soil compaction in agriculture.To overcome the problem, this paper presents a new design of a rigid lugged wheel for us

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Increased expression of the immunoproteasome subunits PSMB8 and PSMB9 by cancer cells correlate with better outcomes for triple-negative breast cancers

Abstract Proteasome dependency is a feature of many cancers that can be targeted by proteasome inhibitors.For some cancer types, notably breast cancer and triple-negative breast cancer (TNBC), high mRNA expression of a modified form of the proteasome, called the immunoproteasome (ImP), correlates with better outcomes and higher expression of one Im

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